Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

16 Dec 2020

Abstract excerpt

gene was amplified, and nuclear HSF1 abundance was markedly increased in prostate cancers and particularly in neuroendocrine prostate cancer (NEPC), for which there are no available treatment options. Despite genetic validation of HSF1 as a therapeutic target in a range of cancers, a direct and selective small-molecule HSF1 inhibitor has not been validated or developed for use in the clinic. We described the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress and Disease
Share to Heat shock proteins research
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33328331
DOI: 10.1126/scitranslmed.abb5647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1PMID 33328331Read ↗

NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer GrowthSemantic proximity Read ↗

Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivitySemantic proximity Read ↗

HSF1 is a novel prognostic biomarker in high-risk prostate cancer that correlates with ferroptosisSemantic proximity Read ↗

Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress via ERK/JNK Pathway in Hyperplastic ProstateSemantic proximity Read ↗

HSF1, a versatile factor in tumorogenesis.Semantic proximity Read ↗

Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells.Semantic proximity Read ↗

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.Semantic proximity Read ↗

SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancerSemantic proximity Read ↗

Non-oncogene addiction and the stress phenotype of cancer cells.Semantic proximity Read ↗

SOX2 expression in prostate cancer drives resistance to nuclear hormone receptor signaling inhibition through the WEE1/CDK1 signaling axisSemantic proximity Read ↗

Targeting TCTP as a New Therapeutic Strategy in Castration-resistant Prostate CancerSemantic proximity Read ↗

Emerging Developments in ETS-Positive Prostate Cancer TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.