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Article

Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status.

The Biochemical journal - 1 Jun 2013

Nguyen Chau H, Lang Benjamin J, Chai Ryan C C, Vieusseux Jessica L, Kouspou Michelle M, Price John T

Abstract excerpt

HSF1 (heat-shock factor 1) is the master regulator of the heat-shock response; however, it is also activated by cancer-associated stresses and supports cellular transformation and cancer progression. We examined the role of HSF1 in relation to cancer cell clonogenicity, an important attribute of cancer cells. Ectopic expression or HSF1 knockdown demonstrated that HSF1 positively regulated cancer cell clonogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23510323
DOI: 10.1042/BJ20130098

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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