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Article

Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways.

Kidney international - 1 Nov 2000

Liu Y, Rajur K, Tolbert E, Dworkin L D

Abstract excerpt

BACKGROUND: Hepatocyte growth factor (HGF) has been shown to promote tubule repair and renal regeneration following acute injury; however, whether HGF also modulates the development and progression of chronic renal diseases that are characterized by progressive tissue fibrosis is uncertain. To ex...

Topics

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Fibrosis
Hepatocyte Growth Factor
Kidney Diseases
Metalloendopeptidases
Nephrectomy
Peptide Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-met

Tissue Inhibitor of Metalloproteinases

Source

Identifiers

PMID: 11044223
DOI: 10.1111/j.1523-1755.2000.00375.x

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11044223-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways.PMID 11044223Read ↗

Constitutive expression of HGF modulates renal epithelial cell phenotype and induces c-met and fibronectin expression.Semantic proximity Read ↗

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of actionSemantic proximity Read ↗

Reciprocal balance of hepatocyte growth factor and transforming growth factor-beta 1 in renal fibrosis in mice.Semantic proximity Read ↗

Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis.Semantic proximity Read ↗

Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros.Semantic proximity Read ↗

Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity.Semantic proximity Read ↗

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[Molecular biology of hepatocyte growth factor (HGF)].Semantic proximity Read ↗

Molecular characteristics of HGF and the gene, and its biochemical aspects.Semantic proximity Read ↗

Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa.Semantic proximity Read ↗

The presence of hepatocyte growth factor in the developing ratSemantic proximity Read ↗

Purification and Cloning of Hepatocyte Growth Factor Activator Inhibitor Type 2, a Kunitz-type Serine Protease InhibitorSemantic proximity Read ↗

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