Article
Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways.
Kidney international - 1 Nov 2000
Liu Y, Rajur K, Tolbert E, Dworkin L D
Abstract excerpt
BACKGROUND: Hepatocyte growth factor (HGF) has been shown to promote tubule repair and renal regeneration following acute injury; however, whether HGF also modulates the development and progression of chronic renal diseases that are characterized by progressive tissue fibrosis is uncertain. To examine this question, this study investigated the functional consequence of blocking endogenous HGF signaling in vivo in...
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