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Article

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action

4 Jun 2004

Abstract excerpt

Hepatocyte growth factor (HGF) is a pleiotropic factor that plays an imperative role in tubular repair and regeneration after acute renal injury. Growing evidence indicates that HGF is also an endogenous renoprotective factor that possesses a potent antifibrotic ability. HGF prevents the initiation and progression of chronic renal fibrosis and inhibits transforming growth factor (TGF)-beta(1) expression in a wide...

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PMID: 15180923
DOI: 10.1152/ajprenal.00451.2003

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