Article
Electroporation-mediated PDGF receptor-IgG chimera gene transfer ameliorates experimental glomerulonephritis.
Kidney international - 1 Jun 2001
Nakamura H, Isaka Y, Tsujie M, Akagi Y, Sudo T, Ohno N, Imai E, Hori M
Abstract excerpt
BACKGROUND: Mesangial cell proliferation and phenotypic alteration occur in an early phase of glomerular injury and precede increased extracellular matrix accumulation. A critical growth factor responsible for mesangial proliferation is platelet-derived growth factor (PDGF), which has proved to be a potent mitogen. METHODS: We generated a chimeric cDNA encoding an extracellular domain of the beta-PDGF receptor...
Topics
- Actins
- Animals
- Cell Division
- Cells, Cultured
- Collagen
- Electroporation
- Extracellular Matrix
- Gene Expression
- Gene Transfer Techniques
- Genetic Therapy
- Glomerular Mesangium