Article
Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats.
Circulation - 22 Mar 2005
Shigemura Norihisa, Sawa Yoshiki, Mizuno Shinya, Ono Masamichi, Ohta Mitsunori, Nakamura Toshikazu, Kaneda Yasufumi, Matsuda Hikaru
Abstract excerpt
BACKGROUND: Hepatocyte growth factor (HGF) is an important mitogen and morphogen that contributes to the repair process after lung injury. The goal of the present study was to characterize its role in pulmonary emphysema, which may lead to the development of new treatment strategies with HGF. METHODS AND RESULTS: HGF mRNA and protein levels in lung tissue and plasma from elastase-induced emphysema rats...
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