Article
Coalescent methods for fine-scale disease-gene mapping.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Morris Andrew P
Abstract excerpt
Fine-scale mapping methods have been developed to localize functional polymorphisms within large candidate regions identified from previous linkage and/or association studies. Population-based association fine-mapping methods utilize linkage disequilibrium of alleles at high-density marker single-nucleotide polymorphisms with the functional polymorphism, generated as the result of shared ancestry of individuals...
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