Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows.

Abstract excerpt

Large-scale haplotype association analysis, especially at the whole-genome level, is still a very challenging task without an optimal solution. In this study, we propose a new approach for haplotype association analysis that is based on a variable-sized sliding-window framework and employs regularized regression analysis to tackle the problem of multiple degrees of freedom in the haplotype test. Our method can...

Topics

• Asian People
• Computer Simulation
• Data Interpretation, Statistical
• Genetic Predisposition to Disease
• Haplotypes
• Humans
• Parkinson Disease
• Polymorphism, Single Nucleotide
• Regression Analysis
• Singapore