Article
The Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men.
The Journal of clinical endocrinology and metabolism - 1 Sept 2006
Jang Yangsoo, Kim Oh Yoen, Koh Soo Jeong, Chae Jey Sook, Ko Young Guk, Kim Ji Young, Cho Hongkeun, Jeong Tae-Sook, Lee Woo Song, Ordovas Jose M, Lee Jong Ho
Abstract excerpt
CONTEXT AND OBJECTIVE: It is unclear whether lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) exerts a pro- or antiatherogenic effect on cardiovascular disease (CVD). We investigated the association between Lp-PLA(2) variant (V279F and A379V) and CVD in Korean men. DESIGN: CVD patients (n = 532) and healthy controls (n = 670) were genotyped for the Lp-PLA(2) polymorphism (V279F and A379V). MAIN OUTCOME...
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