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Article

Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cells.

Nucleic acids research - 1 Jan 2004

Krüger Ines, Rothkamm Kai, Löbrich Markus

Abstract excerpt

The influence of cell cycle phase on the fidelity of DNA double-strand break (DSB) repair is largely unknown. We investigated the rejoining of correct and incorrect DSB ends in synchronized populations of Chinese hamster ovary cells irradiated with 80 Gy X-rays. A specialized pulsed-field gel electrophoresis assay based on quantitative Southern hybridization of individual large restriction fragments was employed...

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Identifiers

PMID: 15148355
DOI: 10.1093/nar/gkh586
PMCID: PMC419594

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