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Article

Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2.

DNA repair - 1 Dec 2020

Zahnreich Sebastian, Weber Britta, Rösch Gundula, Schindler Detlev, Schmidberger Heinz

Abstract excerpt

Fanconi anemia (FA) is a rare chromosomal instability syndrome with various clinical features and high cancer incidence. Despite being a DNA repair disorder syndrome and a frequently observed clinical hypersensitivity of FA patients towards ionizing radiation, the experimental evidence regarding the efficiency of radiation-induced DNA double-strand break (DSB) repair in FA is very controversial. Here, we...

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PMID: 33069004
DOI: 10.1016/j.dnarep.2020.102992

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