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Article

A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair.

Molecular and cellular biology - 1 Jan 2000

Taylor R M, Moore D J, Whitehouse J, Johnson P, Caldecott K W

Abstract excerpt

XRCC1 protein is essential for viability in mammals and is required for efficient DNA single-strand break repair and genetic stability following DNA base damage. We report here that XRCC1-dependent strand break repair in G(1) phase of the cell cycle is abolished by mutations created within the XRCC1 BRCT domain that interact with DNA ligase III. In contrast, XRCC1-dependent DNA strand break repair in S phase is...

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Identifiers

PMID: 10611252
DOI: 10.1128/MCB.20.2.735-740.2000
PMCID: PMC85188

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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