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Article

Pathways of DNA double-strand break repair during the mammalian cell cycle.

Molecular and cellular biology - 1 Aug 2003

Rothkamm Kai, Krüger Ines, Thompson Larry H, Löbrich Markus

Abstract excerpt

Little is known about the quantitative contributions of nonhomologous end joining (NHEJ) and homologous recombination (HR) to DNA double-strand break (DSB) repair in different cell cycle phases after physiologically relevant doses of ionizing radiation. Using immunofluorescence detection of gamma-H2AX nuclear foci as a novel approach for monitoring the repair of DSBs, we show here that NHEJ-defective hamster...

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Identifiers

PMID: 12897142
DOI: 10.1128/MCB.23.16.5706-5715.2003
PMCID: PMC166351

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Source receipt: pubmed, retrieved 7 Sept 2026.

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