Article
Radiation-sensitive irs mutants rejoin DNA double-strand breaks with efficiency similar to that of parental V79 cells but show altered response to radiation-induced G2 delay.
Mutation research - 1 Aug 1992
Cheong N, Wang Y, Jackson M, Iliakis G
Abstract excerpt
Induction and repair of DNA double-strand breaks (dsb) was investigated in plateau phase Chinese hamster V79 cells and three radiosensitive mutant cell lines derived from them, irs-1, irs-2 and irs-3, using a pulsed-field gel electrophoresis assay, Asymmetric Field Inversion Gel Electrophoresis (...
Topics
- Animals
- Cell Cycle
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- DNA Damage
- DNA Repair
- In Vitro Techniques
- Mutation
- X-Rays