Article
An insulin response element in the glyceraldehyde-3-phosphate dehydrogenase gene binds a nuclear protein induced by insulin in cultured cells and by nutritional manipulations in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Nasrin N, Ercolani L, Denaro M, Kong X F, Kang I, Alexander M
Abstract excerpt
Two independent cis-acting insulin response elements (IREs) in the gene encoding glyceraldehyde-3-phosphate dehydrogenase [D-glyceraldehyde-3-phosphate: NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12], designated IRE-A and IRE-B, are sufficient to direct insulin-inducible gene expression. Usi...
Topics
- Animals
- Base Sequence
- Carcinoma, Hepatocellular
- Cell Differentiation
- Cell Line
- Cell Nucleus
- Cells, Cultured
- Chromosome Deletion
- Gene Expression Regulation, Enzymologic
- Glyceraldehyde-3-Phosphate Dehydrogenases
- Humans
- Insulin
- Liver