Article
Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter.
Endocrinology - 1 Oct 1997
Allander S V, Durham S K, Scheimann A O, Wasserman R M, Suwanichkul A, Powell D R
Abstract excerpt
The insulin response element (IRE) of the human insulin-like growth factor-binding protein-1 (IGFBP-1) promoter contains a palindrome of the T(A/G)TTT sequence crucial to hormonal regulation of many genes. In initial studies of how this IRE participates in hormonal regulation, the electromobility...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- DNA
- DNA-Binding Proteins
- HMGA1a Protein
- Hepatocyte Nuclear Factor 3-alpha
- High Mobility Group Proteins
- Humans
- Insulin
- Insulin-Like Growth Factor Binding Protein 1
- Liver Neoplasms
- Mutation
- Nuclear Proteins
- Oligonucleotides