Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.

The Biochemical journal - 15 Nov 2006

Dif Nicolas, Euthine Vanessa, Gonnet Estelle, Laville Martine, Vidal Hubert, Lefai Etienne

Abstract excerpt

In the present study, we aimed to decipher the mechanisms involved in the transcriptional effect of insulin on the SREBP-1c specific promoter of the human srebf-1 gene. Using luciferase reporter gene constructs in HEK-293 cells (human embryonic kidney cells), we demonstrated that the full effect of insulin requires the presence of SREs (sterol response elements) in the proximal region of the promoter....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin

Share to Muscle, Skeletal

Share to Perfusion

Share to Response Elements

Share to Sterol Regulatory Element Binding Protein 1

Share to Sterol Regulatory Element Binding Protein 2

Source

Open in PubMed Open full text

Identifiers

PMID: 16831124
DOI: 10.1042/BJ20060499
PMCID: PMC1635455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.PMID 16831124Read ↗

Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements.Semantic proximity Read ↗

Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha).Semantic proximity Read ↗

Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle CellsSemantic proximity Read ↗

SREBPs: sterol-regulated transcription factorsSemantic proximity Read ↗

N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha.Semantic proximity Read ↗

Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.Semantic proximity Read ↗

The Insulin-like Growth Factor-binding Protein 1 Gene Is a Primary Target of Peroxisome Proliferator-activated ReceptorsSemantic proximity Read ↗

Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.Semantic proximity Read ↗

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscleSemantic proximity Read ↗

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of GenesSemantic proximity Read ↗

Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes.Semantic proximity Read ↗

Identification of insulin-responsive regions in the HMG-CoA reductase promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.