Identification of cis-elements mediating the stimulation of rat insulin-like growth factor-binding protein-1 promoter activity by dexamethasone, cyclic adenosine 3',5'-monophosphate, and phorbol esters, and inhibition by insulin.

doi:10.1210/mend.8.6.7523864

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Article

Identification of cis-elements mediating the stimulation of rat insulin-like growth factor-binding protein-1 promoter activity by dexamethasone, cyclic adenosine 3',5'-monophosphate, and phorbol esters, and inhibition by insulin.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 1994

Suh D S, Ooi G T, Rechler M M

Abstract excerpt

Insulin-like growth factor-binding protein-1 (IGFBP-1) modulates the action of IGFs on target cells. IGFBP-1 transcription is highly regulated by hormonal and metabolic factors. In rat H4-II-E hepatoma cells, IGFBP-1 messenger RNA is stimulated by dexamethasone, cAMP, and phorbol esters, and dominantly inhibited by insulin. To identify the cis-elements that determine transcriptional regulation by these agents, we...

Topics

Animals
Base Sequence
Carrier Proteins
Cyclic AMP
DNA
Dexamethasone
Enhancer Elements, Genetic
Gene Deletion
Gene Expression Regulation
Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glucocorticoids

Insulin

Insulin-Like Growth Factor Binding Protein 1

Liver Neoplasms, Experimental

Molecular Sequence Data

Mutation

Nucleotides

Phorbol Esters

Source

Open in PubMed

Identifiers

PMID: 7523864
DOI: 10.1210/mend.8.6.7523864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7523864-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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