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Article

Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development.

Development (Cambridge, England) - 1 Aug 2010

Brown J Lesley, Kassis Judith A

Abstract excerpt

The Polycomb group of proteins (PcG) is important for transcriptional repression and silencing in all higher eukaryotes. In Drosophila, PcG proteins are recruited to the DNA by Polycomb-group response elements (PREs), regulatory sequences whose activity depends on the binding of many different sequence-specific DNA-binding proteins. We previously showed that a binding site for the Sp1/KLF family of zinc-finger...

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Identifiers

PMID: 20627963
DOI: 10.1242/dev.047761
PMCID: PMC2927704

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