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Article

Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis.

The American journal of pathology - 1 May 2006

Vogler Susanne, Pahnke Jens, Rousset Sophie, Ricquier Daniel, Moch Holger, Miroux Bruno, Ibrahim Saleh M

Abstract excerpt

Uncoupling protein 2 (UCP2) is a member of the mitochondrial transporter superfamily that is expressed in many tissues, including immune cells. UCP2 prevents oxidative stress by reducing reactive oxygen species. Using UCP2-deficient mice, it was shown that UCP2 is involved in the regulation of insulin secretion, in the resistance to infection, and in atherosclerosis. Here, we investigated the role of UCP2 in...

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Share to Encephalomyelitis, Autoimmune, Experimental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16651623
DOI: 10.2353/ajpath.2006.051069
PMCID: PMC1606603

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis.PMID 16651623Read ↗

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Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational RegulationSemantic proximity Read ↗

The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complicationsSemantic proximity Read ↗

Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels.Semantic proximity Read ↗

Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.Semantic proximity Read ↗

Deletion of mitochondrial uncoupling protein-2 increases ischemic brain damage after transient focal ischemia by altering gene expression patterns and enhancing inflammatory cytokines.Semantic proximity Read ↗

Mitochondrial Uncoupling Protein 2 Knockout Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in a Mouse Model of GlaucomaSemantic proximity Read ↗

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Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.Semantic proximity Read ↗

Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis.Semantic proximity Read ↗

Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice.Semantic proximity Read ↗

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