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Article

Uncoupling Protein 2 Inhibits Myointimal Hyperplasia in Preclinical Animal Models of Vascular Injury.

Journal of the American Heart Association - 12 Oct 2017

Zhang Yan, Zhang Yaolei, Li Wei, Wang Peijian, Gu Rui, Feng Yaxing, Wei Shujie, Peng Ke, Zhang Yunrong, Su Linan, Wang Qiang, Li De, Yang Dachun, Wong Wing Tak, Yang Yongjian, Ma Shuangtao

Abstract excerpt

BACKGROUND: Intracoronary stent restenosis, characterized by excessive smooth muscle cell (SMC) proliferation and myointimal hyperplasia, remains a clinical challenge. Mitochondrial membrane potential has been linked to the proliferative rate of SMCs. This study aimed to screen a critical gene regulating mitochondrial potential and to confirm its effects on myointimal formation in preclinical animal models....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29025747
DOI: 10.1161/JAHA.117.006593
PMCID: PMC5721816

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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