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Article

The influence of St John's Wort on CYP2C19 activity with respect to genotype.

Journal of clinical pharmacology - 1 Jun 2004

Wang Lian-Sheng, Zhu Bing, Abd El-Aty A M, Zhou Gan, Li Zhi, Wu Jun, Chen Guo-Lin, Liu Jie, Tang Zhi Rong, An Wang, Li Qing, Wang Dan, Zhou Hong-Hao

Abstract excerpt

Induction of cytochrome p450 isozymes is the major cause for clinical drug interactions of St. John's wort. The relationships of St. John's wort to cytochrome p450 isoforms have been fully investigated, but its effect on CYP2C19 is lacking. Thus, the aim of the present study was to observe the effect of St. John's wort on CYP2C19 activity using CYP1A2 as a control. Twelve healthy adult men-6 extensive...

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Identifiers

PMID: 15145964
DOI: 10.1177/0091270004265642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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