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The effect of induction of CYP3A4 by St John's wort on ambrisentan plasma pharmacokinetics in volunteers of known CYP2C19 genotype.

Basic & clinical pharmacology & toxicology - 1 May 2015

Markert Christoph, Kastner Ida Maria, Hellwig Regina, Kalafut Peter, Schweizer Yvonne, Hoffmann Michael Marcus, Burhenne Jürgen, Weiss Johanna, Mikus Gerd, Haefeli Walter Emil

Abstract excerpt

To evaluate the impact of CYP2C19 polymorphisms on ambrisentan exposure and to assess its modification by St. John's wort (SJW), 20 healthy volunteers (10 CYP2C19 extensive, four poor and six ultrarapid metabolizers) received therapeutic doses of ambrisentan (5 mg qd po) for 20 days and concomita...

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PMID: 25286744
DOI: 10.1111/bcpt.12332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25286744-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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