Article
Evaluation of methods for achieving stable INR in healthy subjects during a multiple-dose warfarin study.
European journal of clinical pharmacology - 1 Mar 2012
Chappell Jill C, Dickinson Gemma, Mitchell Malcolm I, Haber Harry, Jin Yan, Lobo Evelyn D
Abstract excerpt
PURPOSE: No consistent method is available for finding stable warfarin maintenance doses and fast stabilization of international normalized ratio (INR) values among healthy subjects in experimental warfarin interaction studies. Using data from an earlier study that targeted a stable INR of 1.5-2....
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