Article
ATP potentiates agrin-induced AChR aggregation in cultured myotubes: activation of RhoA in P2Y1 nucleotide receptor signaling at vertebrate neuromuscular junctions.
The Journal of biological chemistry - 23 Jul 2004
Ling Karen K Y, Siow Nina L, Choi Roy C Y, Ting Annie K L, Kong Ling W, Tsim Karl W K
Abstract excerpt
At vertebrate neuromuscular junctions, ATP is known to stabilize acetylcholine in the synaptic vesicles and to be co-released with it. We have shown previously that a nucleotide receptor, P2Y(1) receptor, is localized at the nmjs, and we propose that this mediates a trophic role for synaptic ATP there. In cultured myotubes, the activation of P2Y(1) receptors modulated agrin-induced acetylcholine receptor (AChR)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.