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Article

Rapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptor.

Neuroscience - 2 Jun 2008

Lee Y, Rudell J, Yechikhov S, Taylor R, Swope S, Ferns M

Abstract excerpt

At the developing vertebrate neuromuscular junction, postsynaptic localization of the acetylcholine receptor (AChR) is regulated by agrin signaling via the muscle specific kinase (MuSK) and requires an intracellular scaffolding protein called rapsyn. In addition to its structural role, rapsyn is also necessary for agrin-induced tyrosine phosphorylation of the AChR, which regulates some aspects of receptor...

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Identifiers

PMID: 18436384
DOI: 10.1016/j.neuroscience.2008.03.009
PMCID: PMC2587422

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Related research

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Rapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptor.PMID 18436384Read ↗

A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndromeSemantic proximity Read ↗

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Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.Semantic proximity Read ↗

The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.Semantic proximity Read ↗

The role of Rapsyn in neuromuscular junction and congenital myasthenic syndromeSemantic proximity Read ↗

MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticitySemantic proximity Read ↗

The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapsesSemantic proximity Read ↗

Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure.Semantic proximity Read ↗

The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functionsSemantic proximity Read ↗

Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish.Semantic proximity Read ↗

Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome.Semantic proximity Read ↗

Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.Semantic proximity Read ↗

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