Article
CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population.
The Journal of infectious diseases - 1 Jun 2007
Inoue Yuzaburo, Shimojo Naoki, Suzuki Yoichi, Campos Alberto Eduardo Jose, Yamaide Akiko, Suzuki Shuichi, Arima Takayasu, Matsuura Tomoko, Tomiita Minako, Aoyagi Masahiko, Hoshioka Akira, Honda Akihito, Hata Akira, Kohno Yoichi
Abstract excerpt
BACKGROUND: The contribution that genetic polymorphisms of Toll-like receptor (TLR) 4 and of CD14--both of which recognize respiratory syncytial virus (RSV) in the innate immune response--make to RSV bronchiolitis in the Japanese population has not yet been clarified. METHODS: This study genotyped 2 TLR4 mutations, Asp299Gly and Thr399Ile, and 2 single-nucleotide polymorphisms (SNPs) of CD14, -550 C/T and -159...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.