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Article

Genetic variation in white matter hyperintensity volume in the Framingham Study.

Stroke - 1 Jul 2004

Atwood Larry D, Wolf Philip A, Heard-Costa Nancy L, Massaro Joseph M, Beiser Alexa, D'Agostino Ralph B, DeCarli Charles

Abstract excerpt

BACKGROUND AND PURPOSE: In a previous study of normal elderly male twins, the heritability of quantitative white matter hyperintensity (WMH) volume has been estimated to be high (0.73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and the impact of age. METHODS: Brain magnetic resonance scans were performed on 2012 individuals in the cohort and...

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Identifiers

PMID: 15143299
DOI: 10.1161/01.STR.0000129643.77045.10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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