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Article

Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume.

Stroke - 1 Dec 2009

Kochunov Peter, Glahn David, Winkler Anderson, Duggirala Ravindranath, Olvera Rene L, Cole Shelley, Dyer Thomas D, Almasy Laura, Fox Peter T, Blangero John

Abstract excerpt

BACKGROUND AND PURPOSE: The cerebral volume of T2-hyperintense white matter (HWM) is an important neuroimaging marker of cerebral integrity. Pathophysiology studies identified that subcortical and ependymal HWM are produced by 2 different mechanisms but shared a common risk factor: high arterial pulse pressure. Recent studies have demonstrated high heritability of the whole-brain HMW volume and reported...

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Identifiers

PMID: 19834011
DOI: 10.1161/STROKEAHA.109.565390
PMCID: PMC2787844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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