Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis.

Arthritis research & therapy - 1 Jan 2004

Dörr Sylvia, Lechtenböhmer Nadine, Rau Rolf, Herborn Gertraud, Wagner Ulf, Müller-Myhsok Bertram, Hansmann Ingo, Keyszer Gernot

Abstract excerpt

The genetic background of rheumatoid arthritis (RA) is only partly understood, and several genes seem to be involved. The matrix metalloproteinases MMP1 (interstitial collagenase) and MMP3 (stromelysin 1) are thought to be important in destructive joint changes seen in RA. In the present study, functional relevant promoter polymorphisms of MMP1 and MMP3 were genotyped in 308 patients and in 110 controls, to test...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to HLA-DR1 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DR4 Antigen

Share to Joints

Share to Linkage Disequilibrium

Share to Matrix Metalloproteinase 1

Share to Matrix Metalloproteinase 3

Share to Radiography

Source

Open in PubMed Open full text

Identifiers

PMID: 15142265
DOI: 10.1186/ar1164
PMCID: PMC416441

Genes

MMP1
MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis.PMID 15142265Read ↗

Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms: Association with severity and progression of rheumatoid arthritis in a prospective study.Semantic proximity Read ↗

Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis.Semantic proximity Read ↗

Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis.Semantic proximity Read ↗

Collagenase-1 (MMP-1) and HLA-DRB1 gene polymorphisms in rheumatoid arthritis: a prospective longitudinal study.Semantic proximity Read ↗

Association of the 5A/6A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis.Semantic proximity Read ↗

Variation of matrix metalloproteinase 1 and 3 haplotypes and their serum levels in patients with rheumatoid arthritis and osteoarthritis.Semantic proximity Read ↗

A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis.Semantic proximity Read ↗

Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis.Semantic proximity Read ↗

Variation in the matrix metalloproteinase‐3, ‐7, ‐12 and ‐13 genes is associated with functional status in rheumatoid arthritisSemantic proximity Read ↗

HLA markers and prediction of clinical course and outcome in rheumatoid arthritis.Semantic proximity Read ↗

Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis.Semantic proximity Read ↗

Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.