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Article

Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis.

Rheumatology international - 1 Jan 2010

Scherer Sabrina, de Souza Thais Barboza, de Paoli Juliana, Brenol Claiton Viegas, Xavier Ricardo Machado, Brenol João Carlos Tavares, Chies José Artur, Simon Daniel

Abstract excerpt

Several genetic factors seem to be involved in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to analyze whether functional polymorphisms in the promoter region of the MMP-1, -3 and -9 genes were associated with RA. The study population comprises 110 RA patients and 100 healthy controls. The -1607 1G/2G MMP-1, -1171 5A/6A MMP-3, and -1562 C/T MMP-9 polymorphisms were analyzed. The...

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PMID: 19504098
DOI: 10.1007/s00296-009-0974-8

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