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Article

Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis.

Genes and immunity - 1 Mar 2004

Mattey D L, Nixon N B, Dawes P T, Ollier W E R, Hajeer A H

Abstract excerpt

Matrix metalloproteinases (MMPs) are implicated in joint destruction in rheumatoid arthritis (RA). We investigated whether the 5A/6A polymorphism within the MMP-3 (stromelysin-1) gene promoter region is associated with disease outcome in 254 patients with established RA. Patients homozygous for the MMP-3 6A allele had more radiographic damage (measured by Larsen score) than those with other genotypes (109.8 vs...

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Identifiers

PMID: 14712311
DOI: 10.1038/sj.gene.6364050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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