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Article

Mapping of a Leishmania major gene/locus that confers pentamidine resistance by deletion and insertion of transposable element.

Revista do Instituto de Medicina Tropical de Sao Paulo - 1 Jan 2000

Coelho Adriano C, Tosi Luiz R O, Cotrim Paulo C

Abstract excerpt

Pentamidine (PEN) is an alternative compound to treat antimony-resistant leishmaniasis patients, which cellular target remains unclear. One approach to the identification of prospective targets is to identify genes able to mediate PEN resistance following overexpression. Starting from a genomic library of transfected parasites bearing a multicopy episomal cosmid vector containing wild-type Leishmania major DNA,...

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PMID: 15141283
DOI: 10.1590/s0036-46652004000200010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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