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Article

Leishmania spp. genetic factors associated with cutaneous leishmaniasis antimony pentavalent drug resistance: a systematic review.

Memorias do Instituto Oswaldo Cruz - 1 Jan 2024

Nery Raphaela Lisboa Andrade, Santos Thaline Mabel Sousa, Gois Luana Leandro, Barral Aldina, Khouri Ricardo, Feitosa Caroline Alves, Santos Luciane Amorim

Abstract excerpt

BACKGROUND: Leishmaniasis is a neglected zoonosis caused by parasites of Leishmania spp. The main drug used to treat cutaneous leishmaniasis (CL) is the antimoniate of meglumine. This drug, which has strong adverse and toxic effects, is usually administered intravenously, further complicating the difficult treatment. Factors such as Leishmania gene expression and genomic mutations appear to play a role in the...

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Identifiers

PMID: 39230137
DOI: 10.1590/0074-02760230240
PMCID: PMC11370656

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