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Article

Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania.

Molecular microbiology - 1 Apr 2013

Mukherjee Angana, Boisvert Sébastien, Monte-Neto Rubens Lima do, Coelho Adriano C, Raymond Frederic, Mukhopadhyay Rita, Corbeil Jacques, Ouellette Marc

Abstract excerpt

Antimonials are still the mainstay of treatment against leishmaniasis but drug resistance is increasing. We carried out short read next-generation sequencing (NGS) and comparative genomic hybridization (CGH) of three independent Leishmania major antimony-resistant mutants. Copy number variations were consistently detected with both NGS and CGH. A major attribute of antimony resistance was a novel terminal...

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Identifiers

PMID: 23421749
DOI: 10.1111/mmi.12178

Genes

AQP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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