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Article

HCMV IE2-mediated inhibition of HAT activity downregulates p53 function.

The EMBO journal - 2 Jun 2004

Hsu Chih-Hung, Chang Margaret D T, Tai Kang-Yu, Yang Yu-Ting, Wang Pei-Shan, Chen Chi-Ju, Wang Yan-Hsiung, Lee Sheng-Chung, Wu Cheng-Wen, Juan Li-Jung

Abstract excerpt

Targeting of cellular histone acetyltransferases (HATs) by viral proteins is important in the development of virus-associated diseases. The immediate-early 2 protein (IE2) of human cytomegalovirus (HCMV) binds to the tumor suppressor, p53, and inactivates its functions by unknown mechanisms. Here, we show that IE2 binds to the HAT domain of the p53 coactivators, p300 and CREB-binding protein (CBP), and blocks...

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Identifiers

PMID: 15141169
DOI: 10.1038/sj.emboj.7600239
PMCID: PMC419916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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