Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2004

Nevels Michael, Paulus Christina, Shenk Thomas

Abstract excerpt

The human cytomegalovirus 72-kDa immediate-early (IE)1 and 86-kDa IE2 proteins are expressed at the start of infection, and they are believed to exert much of their function through promiscuous transcriptional activation of viral and cellular gene expression. Here, we show that the impaired growth of an IE1-deficient mutant virus in human fibroblasts is efficiently rescued by histone deacetylase (HDAC) inhibitors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cytomegalovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Histones

Share to Immediate-Early Proteins

Share to Transcriptional Activation

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 15572445
DOI: 10.1073/pnas.0407933101
PMCID: PMC535392

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.PMID 15572445Read ↗

Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblastsSemantic proximity Read ↗

Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein FunctionSemantic proximity Read ↗

Autorepression of the Human Cytomegalovirus Major Immediate-Early Promoter/Enhancer at Late Times of Infection Is Mediated by the Recruitment of Chromatin Remodeling Enzymes by IE86Semantic proximity Read ↗

Dynamic histone H3 acetylation and methylation at human cytomegalovirus promoters during replication in fibroblasts.Semantic proximity Read ↗

Human Cytomegalovirus UL29/28 Protein Interacts with Components of the NuRD Complex Which Promote Accumulation of Immediate-Early RNASemantic proximity Read ↗

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host ResponsesSemantic proximity Read ↗

Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progressionSemantic proximity Read ↗

A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signalingSemantic proximity Read ↗

Repression of the major immediate early promoter of human cytomegalovirus allows transcription from an alternate promoter.Semantic proximity Read ↗

Chromatin control of human cytomegalovirus infectionSemantic proximity Read ↗

Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cellsSemantic proximity Read ↗

SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.