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Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts

17 Nov 2007

Abstract excerpt

In human cytomegalovirus (HCMV)-infected cells, the 86 kDa immediate-early (IE) 2 protein plays a key role in transactivating downstream viral genes. Recently, IE2 has been shown to interact with histone deacetylase 1 (HDAC1) and HDAC3. HDAC1 recruited by IE2 was required for IE2-mediated autorepression of the major IE (MIE) promoter, whereas IE2-HDAC3 interaction was suggested to relieve the repressive effect of...

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PMID: 18024889
DOI: 10.1099/vir.0.83171-0

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