Article
Genetic correlational analysis of glycogen synthase kinase-3 beta and prepulse inhibition in inbred mice.
Genes, brain, and behavior - 1 Jun 2004
Amar S, Jones B C, Nadri C, Kozlovsky N, Belmaker R H, Agam G
Abstract excerpt
In humans, GSK-3 beta activity is diminished in schizophrenic patients as is prepulse inhibition of the startle response (PPI). We performed a genetic correlational analysis between published PPI values and frontal cortex GSK-3 activity analyzed in our laboratory in 10 inbred mouse strains. This methodology could indicate relevant parameters for study in an animal model. Indeed, we obtained significant...
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