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Article

Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain.

The Biochemical journal - 1 Aug 2004

Cross Janet V, Templeton Dennis J

Abstract excerpt

Many intracellular signalling events are accompanied by generation of reactive oxygen species in cells. Oxidation of protein thiol groups is an emerging theme in signal-transduction research. We have found that MEKK1 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase kinase 1], an upstream activator of the SAPK/JNK (stress-activated protein kinase/c-Jun N-terminal kinase)...

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Identifiers

PMID: 15139849
DOI: 10.1042/BJ20040591
PMCID: PMC1133876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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