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Article

Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria.

PloS one - 11 Jun 2008

Galli Soledad, Antico Arciuch Valeria Gabriela, Poderoso Cecilia, Converso Daniela Paola, Zhou Qiongqiong, Bal de Kier Joffé Elisa, Cadenas Enrique, Boczkowski Jorge, Carreras María Cecilia, Poderoso Juan José

Abstract excerpt

Mitochondria are major cellular sources of hydrogen peroxide (H(2)O(2)), the production of which is modulated by oxygen availability and the mitochondrial energy state. An increase of steady-state cell H(2)O(2) concentration is able to control the transition from proliferating to quiescent phenotypes and to signal the end of proliferation; in tumor cells thereby, low H(2)O(2) due to defective mitochondrial...

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Identifiers

PMID: 18545666
DOI: 10.1371/journal.pone.0002379
PMCID: PMC2398776

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Source receipt: pubmed, retrieved 7 Sept 2026.

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