Article
Oxidation phenotyping with debrisoquine in Germany (East).
Die Pharmazie - 1 Dec 1990
Zschiesche M, Hanke W, Siegmund W, Franke G, Wilke A
Abstract excerpt
An hplc method is described which determines debrisoquine and its metabolite, 4-hydroxydebrisoquine, quantitatively after conversion of the guanidine moieties into the corresponding pyrimidines. Sensitivity, precision, and accuracy have been sufficient enough for the reliable hydroxylation phenot...
Topics
- Adult
- Aged
- Aged, 80 and over
- Chromatography, High Pressure Liquid
- Debrisoquin
- Female
- Germany
- Humans
- Male
- Middle Aged
- Oxidation-Reduction
- Phenotype
- Spectrophotometry, Ultraviolet