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Article

Oxidation phenotyping with debrisoquine in Germany (East).

Die Pharmazie - 1 Dec 1990

Zschiesche M, Hanke W, Siegmund W, Franke G, Wilke A

Abstract excerpt

An hplc method is described which determines debrisoquine and its metabolite, 4-hydroxydebrisoquine, quantitatively after conversion of the guanidine moieties into the corresponding pyrimidines. Sensitivity, precision, and accuracy have been sufficient enough for the reliable hydroxylation phenotyping of 145 non-related healthy volunteers (64 males, 81 females, 31-80 years). 17 (11%) were poor metabolizers of...

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PMID: 2100800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oxidation phenotyping with debrisoquine in Germany (East).PMID 2100800Read ↗

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