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Article

Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers.

Journal of human genetics - 1 Jan 2004

Hirata Tomomi, Nagai Hisaki, Koizumi Kiyoshi, Okino Keiko, Harada Akima, Onda Masamitsu, Nagahata Takemitsu, Mikami Iwao, Hirai Kyoji, Haraguchi Syuji, Jin Enjing, Kawanami Oichi, Shimizu Kazuo, Emi Mitsuru

Abstract excerpt

The Ras-CRK-Rap1 cellular signal-transduction system is regulated by guanine nucleotide exchange factors (GEFs). Transcription of C3G on chromosome 9q34 and a key member of the GEF gene family is activated by the CRK-adaptor protein; the C3G product is a CRK SH3 domain-binding guanine nucleotide-releasing factor. We document here the amplification of C3G in five of 18 primary non-small cell lung cancers examined...

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Share to Adaptor Proteins, Signal Transducing
Share to Adaptor Proteins, Vesicular Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 9

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Source

Identifiers

PMID: 15138850
DOI: 10.1007/s10038-004-0148-1

Genes

CRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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