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Article

Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas.

Oncogene - 11 Sept 2003

Miller Charles T, Chen Guoan, Gharib Tarek G, Wang Hong, Thomas Dafydd G, Misek David E, Giordano Thomas J, Yee John, Orringer Mark B, Hanash Samir M, Beer David G

Abstract excerpt

The C-CRK gene, cellular homolog of the avian v-crk oncogene, encodes two alternatively spliced adaptor signaling proteins, CRKI (28 kDa) and CRKII (40 kDa). Both CRKI and CRKII have been shown to activate kinase signaling and anchorage-independent growth in vitro and CRKI transformed cells readily form tumors in nude mice. Affymetrix oligonucleotide arrays were used to analyse 86 lung adenocarcinomas and 10...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12970743
DOI: 10.1038/sj.onc.1206529

Genes

CRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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