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Article

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.

Cancer discovery - 1 Dec 2011

Cheung Hihu Wing, Du Jinyan, Boehm Jesse S, He Frank, Weir Barbara A, Wang Xiaoxing, Butaney Mohit, Sequist Lecia V, Luo Biao, Engelman Jeffrey A, Root David E, Meyerson Matthew, Golub Todd R, Jänne Pasi A, Hahn William C

Abstract excerpt

UNLABELLED: We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non-small cell lung cancer (NSCLC) cells that harbor 22q11.21 amplifications. Overexpression of CRKL in immortalized human airway epithelial cells promoted anchorage-independent growth...

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Source

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Identifiers

PMID: 22586683
DOI: 10.1158/2159-8290.CD-11-0046
PMCID: PMC3353720

Genes

CRKL
EGFR
SOS1
SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.PMID 22586683Read ↗

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