Article
Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2009
Lai Kevin, Amsterdam Adam, Farrington Sarah, Bronson Roderick T, Hopkins Nancy, Lees Jacqueline A
Abstract excerpt
We have characterized 28 zebrafish lines with heterozygous mutations in ribosomal protein (rp) genes, and found that 17 of these are prone to develop zebrafish malignant peripheral nerve sheath tumors (zMPNST). Heterozygotes from the vast majority of tumor-prone rp lines were found to be growth-impaired, though not all growth-impaired rp lines were tumor-prone. Significantly, however, the rp lines with the...
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