Article
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.
Disease models & mechanisms - 1 Nov 2012
Shin Jimann, Padmanabhan Arun, de Groh Eric D, Lee Jeong-Soo, Haidar Sam, Dahlberg Suzanne, Guo Feng, He Shuning, Wolman Marc A, Granato Michael, Lawson Nathan D, Wolfe Scot A, Kim Seok-Hyung, Solnica-Krezel Lilianna, Kanki John P, Ligon Keith L, Epstein Jonathan A, Look A Thomas
Abstract excerpt
Neurofibromatosis type 1 (NF1) is a common, dominantly inherited genetic disorder that results from mutations in the neurofibromin 1 (NF1) gene. Affected individuals demonstrate abnormalities in neural-crest-derived tissues that include hyperpigmented skin lesions and benign peripheral nerve sheath tumors. NF1 patients also have a predisposition to malignancies including juvenile myelomonocytic leukemia (JMML),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.