Article
Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.
EMBO molecular medicine - 1 Apr 2017
Ajore Ram, Raiser David, McConkey Marie, Jöud Magnus, Boidol Bernd, Mar Brenton, Saksena Gordon, Weinstock David M, Armstrong Scott, Ellis Steven R, Ebert Benjamin L, Nilsson Björn
Abstract excerpt
Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large-scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across human cancers. We found that hemizygous RPG deletions are common,...
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