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Article

The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions.

The Journal of biological chemistry - 16 Jul 2004

Malliri Angeliki, van Es Saskia, Huveneers Stephan, Collard John G

Abstract excerpt

Rho family proteins are essential for the formation of adherens junctions, which are required for the maintenance of epithelial integrity. Activated Rac and the Rac exchange factor Tiam1 have been shown to promote the formation of adherens junctions and the accompanying induction of an epithelioid phenotype in a number of cell lines. Here we show that Madin-Darby canine kidney II cells in which Tiam1 was...

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Identifiers

PMID: 15138270
DOI: 10.1074/jbc.M401192200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions.PMID 15138270Read ↗

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