Article
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact.
Molecular biology of the cell - 1 Mar 2004
Noritake Jun, Fukata Masaki, Sato Kazumasa, Nakagawa Masato, Watanabe Takashi, Izumi Nanae, Wang Shujie, Fukata Yuko, Kaibuchi Kozo
Abstract excerpt
The small guanosine triphosphatase Rac1 is activated by E-cadherin-mediated cell-cell adhesion and is required for the accumulation of actin filaments, E-cadherin, and beta-catenin at sites of cell-cell contact. However, the modes of activation and action of Rac1 remain to be clarified. We here found that suppression of IQGAP1, an actin-binding protein and an effector of Rac1, by small interfering RNA apparently...
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